Reduction-Sensitive Dual Functional Nanomicelles for Improved Delivery of Paclitaxel
نویسندگان
چکیده
منابع مشابه
Reduction-Sensitive Dual Functional Nanomicelles for Improved Delivery of Paclitaxel
We have developed a dual-functional nanocarrier composed of a hydrophilic polyethylene glycol (PEG) and a hydrophobic farnesylthiosalicylate (FTS, a nontoxic Ras antagonist), which is effective in delivery of hydrophobic anticancer drug, paclitaxel (PTX). To facilitate the retention of the therapeutic activity of the carrier, FTS was coupled to PEG via a reduction-sensitive disulfide linkage (P...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2014
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc500292j